Open AccessNew Perspectives on Immune Involvement in Parkinson’s Disease Pathogenesis
Author(s) -
David Gate
Publication year - 2022
Publication title -
journal of parkinson's disease/journal of parkinson's disease (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.747
H-Index - 45
eISSN - 1877-718X
pISSN - 1877-7171
DOI - 10.3233/jpd-223240
Subject(s) - immune system , disease , immunology , pathogenesis , immunogenetics , immune dysregulation , parkinson's disease , genetic predisposition , medicine , autoimmune disease , etiology , antibody , pathology
Accumulating evidence implicates immune dysfunction in the etiology of Parkinson's disease (PD). For instance, impaired cellular and humoral immune responses are emerging as established pathological hallmarks in PD. Further, in experimental models of PD, inflammatory cell activation and immune dysregulation are evident. Genetic and epidemiologic studies have drawn associations between autoimmune disease and PD. Distillation of these various lines of evidence indicates dysregulated immunogenetics as a primary risk factor for PD. This article will present novel perspectives on the association between genetic risk factors and immune processes in PD. The objective of this work is to synthesize the data surrounding the role of immunogenetics in PD to maximize the potential of targeting the immune system as a therapeutic modality.