Open AccessRoles of Non-Coding RNAs as Novel Diagnostic Biomarkers in Parkinson’s Disease
Author(s) -
Ida Manna,
Andrea Quattrone,
Selene De Benedittis,
Enrico Iaccino,
Aldo Quattrone
Publication year - 2021
Publication title -
journal of parkinson's disease/journal of parkinson's disease (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.747
H-Index - 45
eISSN - 1877-718X
pISSN - 1877-7171
DOI - 10.3233/jpd-212726
Subject(s) - microrna , parkinson's disease , disease , non coding rna , diagnostic biomarker , long non coding rna , biomarker , bioinformatics , computational biology , medicine , rna , biology , pathology , genetics , gene
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting 5%of the elderly population. Currently, the diagnosis of PD is mainly based on clinical features and no definitive diagnostic biomarkers have been identified. The discovery of biomarkers at the earliest stages of PD is of extreme interest. This review focuses on the current findings in the field of circulating non-coding RNAs in PD. We briefly describe the more established circulating biomarkers in PD and provide a more thorough review of non-coding RNAs, in particular microRNAs, long non-coding RNAs and circular RNAs, differentially expressed in PD, highlighting their potential for being considered as biomarkers for diagnosis. Together, these studies hold promise for the use of peripheral biomarkers for the diagnosis of PD.