Open AccessChallenges and Perspectives in the Management of Late-Stage Parkinson’s Disease
Author(s) -
Margherita Fabbri,
Linda Azevedo Kauppila,
Joaquim J. Ferreira,
Olivier Rascol
Publication year - 2020
Publication title -
journal of parkinson's disease/journal of parkinson's disease (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.747
H-Index - 45
eISSN - 1877-718X
pISSN - 1877-7171
DOI - 10.3233/jpd-202096
Subject(s) - disease , medicine , parkinson's disease , stage (stratigraphy) , intensive care medicine , multidisciplinary approach , palliative care , psychological intervention , disease management , population , meaning (existential) , psychology , psychiatry , psychotherapist , pathology , nursing , paleontology , social science , environmental health , sociology , biology
Parkinson’s disease (PD) is a common neurodegenerative disorder, with a continuously increasing prevalence. With improved clinical and therapeutic management of PD, more patients reach later stages of the disease, meaning they may face new clinical problems that were not commonly approached. This gave way to the description of a new PD stage, late-stage PD (LSPD), which is clinically discernible from the advanced-stage one. Therefore, LSPD patients have new and different needs, regarding pharmacological and non pharmacological interventions, including palliative care and multidisciplinary teams. LSPD patients constitute an‘orphan population’, who traditionally was excluded from previous studies, due to its high disability. With this manuscript, we intend to review specific management challenges of LSPD patients, covering this new concept and its clinical features, how to assess these patients, therapeutic recommendations, as well as discussing ongoing research and future perspectives.