Open AccessCurrent View of Diagnosing Small Fiber Neuropathy
Author(s) -
Lisette Raasing,
O.J.M. Vogels,
Marcel Veltkamp,
Christiaan F. P. van Swol,
Jan C. Grutters
Publication year - 2021
Publication title -
journal of neuromuscular diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.366
H-Index - 23
eISSN - 2214-3602
pISSN - 2214-3599
DOI - 10.3233/jnd-200490
Subject(s) - medicine , pathophysiology , disease , sensory system , fiber , diagnostic accuracy , quality of life (healthcare) , neuroscience , biology , nursing , chemistry , organic chemistry
Small fiber neuropathy (SFN) is a disorder of the small myelinated Aδ-fibers and unmyelinated C-fibers [5, 6]. SFN might affect small sensory fibers, autonomic fibers or both, resulting in sensory changes, autonomic dysfunction or combined symptoms [7]. As a consequence, the symptoms are potentially numerous and have a large impact on quality of life [8]. Since diagnostic methods for SFN are numerous and its pathophysiology complex, this extensive review focusses on categorizing all aspects of SFN as disease and its diagnosis. In this review, sensitivity in combination with specificity of different diagnostic methods are described using the areas under the curve. In the end, a diagnostic work-flow is suggested based on different phenotypes of SFN.