Open AccessEnhancement of Satellite Cell Transplantation Efficiency by Leukemia Inhibitory Factor
Author(s) -
Naoki Ito,
Noriaki Shimizu,
Hirotoshi Tanaka,
Shin’ichi Takeda
Publication year - 2016
Publication title -
journal of neuromuscular diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.366
H-Index - 23
eISSN - 2214-3602
pISSN - 2214-3599
DOI - 10.3233/jnd-160156
Subject(s) - transplantation , satellite , leukemia inhibitory factor , stem cell , cell , duchenne muscular dystrophy , medicine , cancer research , cell culture , muscular dystrophy , immunology , microbiology and biotechnology , biology , biochemistry , genetics , interleukin 6 , cytokine , engineering , aerospace engineering
Cell transplantation is a promising therapy for several muscle diseases, including Duchenne muscular dystrophy. Satellite cells are stem cells in skeletal muscle that provide an important cell source for transplantation therapy. However, culture of satellite cells in vitro causes them to lose their undifferentiated state, associated with reduced transplantation efficiency. It is therefore necessary to develop optimal culture conditions for maintaining the undifferentiated state of satellite cells.