Open AccessEffect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk
Author(s) -
Alina Solomon,
Ron Handels,
Anders Wimo,
Riitta Antikaínen,
Tiina Laatikainen,
Esko Levälahti,
Markku Peltonen,
Hilkka Soininen,
Timo Strandberg,
Jaakko Tuomilehto,
Miia Kivipelto,
Tiia Ngandu
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-210331
Subject(s) - dementia , intervention (counseling) , medicine , randomized controlled trial , relative risk , physical therapy , post hoc analysis , gerontology , psychiatry , disease , confidence interval
We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60–77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was –0.16 (95 %CI –0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04–6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.