Open AccessLocal Contrasts in Concentration of Ambient Particulate Air Pollution (PM2.5) and Incidence of Alzheimer’s Disease and Dementia: Results from the Betula Cohort in Northern Sweden
Author(s) -
Daniel Oudin Åström,
Rolf Adolfsson,
David Segersson,
Bertil Forsberg,
Anna Oudin
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-201538
Subject(s) - dementia , vascular dementia , cohort , hazard ratio , incidence (geometry) , confidence interval , particulates , cohort study , air pollution , environmental health , medicine , particulate pollution , environmental science , disease , gerontology , ecology , biology , physics , optics
Exposure to fine particulate air pollution (PM2.5) is emerging as a risk factor for Alzheimer’s disease (AD), but existing studies are still limited and heterogeneous. We have previously studied the association between dementia (AD and vascular dementia) and PM2.5 stemming from vehicle exhaust and wood-smoke in the Betula cohort in Northern Sweden. The aim of this commentary is to estimate the association between total PM2.5 and dementia in the Betula cohort, which is more relevant to include in future meta-estimates than the source-specific estimates. The hazard ratio for incident dementia associated with a 1μg/m3 increase in local PM2.5 was 1.38 (95% confidence interval: 0.99 –1.92). The interpretation of our results is that they indicate an association between local contrasts in concentration of PM2.5 at the residential address and incidence of dementia in a low-level setting.