Open AccessTAR DNA-Binding Protein 43 Is Associated with Rate of Memory, Functional and Global Cognitive Decline in the Decade Prior to Death
Author(s) -
Marina Buciuc,
Nirubol Tosakulwong,
Mary M. Machulda,
Jennifer L. Whitwell,
Stephen D. Weigand,
Melissa E. Murray,
R. Ross Reichard,
Joseph E. Parisi,
Dennis W. Dickson,
Bradley F. Boeve,
David S. Knopman,
Ronald C. Petersen,
Keith A. Josephs
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-201166
Subject(s) - cognitive decline , episodic memory , clinical dementia rating , dementia , cognition , psychology , hippocampus , effects of sleep deprivation on cognitive performance , alzheimer's disease , disease , audiology , neuroscience , medicine , cognitive impairment
Transactive response DNA-binding protein of 43 kDa (TDP-43) is associated with memory impairment and overall cognitive decline. It is unclear how TDP-43 contributes to the rate of clinical decline.