Open AccessData-Driven Modeling of Knowledge Assemblies in Understanding Comorbidity Between Type 2 Diabetes Mellitus and Alzheimer’s Disease
Author(s) -
Reagon Karki,
Sumit Madan,
Yojana Gadiya,
Daniel DomingoFernándéz,
Alpha Tom Kodamullil,
Martin HofmannApitius
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200752
Subject(s) - genome wide association study , computational biology , type 2 diabetes mellitus , genetics , disease , biology , genetic association , bioinformatics , gene , single nucleotide polymorphism , medicine , diabetes mellitus , pathology , genotype , endocrinology
Recent studies have suggested comorbid association between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) through identification of shared molecular mechanisms. However, the inference is pre-dominantly literature-based and lacks interpretation of pre-disposed genomic variants and transcriptomic measurables.