Open AccessNeuromodulation for Apathy in Alzheimer’s Disease: A Double-Blind, Randomized, Sham-Controlled Pilot Study
Author(s) -
Prasad R. Padala,
Eugenia M Boozer,
Shelly Lensing,
C. Parkes,
Cassandra R. Hunter,
Richard A. Dennis,
Ricardo Cáceda,
Kalpana P. Padala
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200640
Subject(s) - apathy , randomized controlled trial , clinical global impression , medicine , activities of daily living , psychology , physical therapy , disease , placebo , pathology , alternative medicine
Apathy, a profound loss of motivation, initiation, and goal directed cognition, is a common comorbidity of Alzheimer's disease (AD). The presence of apathy is associated with rapid progression of AD, long-term impairment, disability, and higher mortality. Pharmacological treatments of apathy are limited.