Open AccessNeuronal Calcium Imaging, Excitability, and Plasticity Changes in the Aldh2–/– Mouse Model of Sporadic Alzheimer’s Disease
Author(s) -
Adam O. Ghoweri,
Peter J. Gagolewicz,
Hilaree N. Frazier,
John C. Gant,
R. David Andrew,
Brian M. Bennett,
Olivier Thibault
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200617
Subject(s) - long term potentiation , oxidative stress , calcium , neuroscience , synaptic plasticity , psychology , medicine , endocrinology , biology , receptor
Dysregulated signaling in neurons and astrocytes participates in pathophysiological alterations seen in the Alzheimer's disease brain, including increases in amyloid-β, hyperphosphorylated tau, inflammation, calcium dysregulation, and oxidative stress. These are often noted prior to the development of behavioral, cognitive, and non-cognitive deficits. However, the extent to which these pathological changes function together or independently is unclear.