Open AccessAllelic Distribution of Genes for Apolipoprotein E and MTHFR in Patients with Alzheimer’s Disease and Their Epistatic Interaction
Author(s) -
Stanislav Šutovský,
Róbert Petrovič,
Mária Fischerová,
Viera Haverlíková,
Barbara Ukropcová,
Jozef Ukropec,
Peter Turčáni
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200321
Subject(s) - methylenetetrahydrofolate reductase , epistasis , apolipoprotein e , allele , genotype , genetics , heterozygote advantage , biology , gene interaction , medicine , gene , disease
Genetic risk factors play an important role in the pathogenesis of Alzheimer's disease (AD). However, the gene-gene interaction (epistasis) between specific allelic variants is only partially understood.