Open AccessIntranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice
Author(s) -
Yun Shi,
Lei Zhang,
Xue Gao,
Jing Zhang,
Matan Ben Abou,
Liang Ge,
Qingcheng Meng,
Adrian Hepner,
Maryellen F. Eckenhoff,
Huafeng Wei
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200227
Subject(s) - medicine , dantrolene , nasal administration , subcutaneous injection , morris water navigation task , pharmacology , anesthesia , hippocampus , calcium
This study compares the effectiveness and safety of intranasal versus subcutaneous administration of dantrolene in 5XFAD Alzheimer's disease (AD) mice.