Open AccessAstrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer’s Disease
Author(s) -
Benjamin B. Tournier,
Stergios Tsartsalis,
Kelly Ceyzériat,
B. Fraser,
MarieClaude Grégoire,
Eniko Veronika Kovari,
Philippe Millet
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200136
Subject(s) - translocator protein , microglia , downregulation and upregulation , neuroinflammation , neuroscience , cell , astrocyte , hippocampus , pathology , population , biology , chemistry , microbiology and biotechnology , medicine , immunology , disease , inflammation , central nervous system , biochemistry , environmental health , gene
In vivo PET/SPECT imaging of neuroinflammation is primarily based on the estimation of the 18 kDa-translocator-protein (TSPO). However, TSPO is expressed by different cell types which complicates the interpretation.