Open AccessAPOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer’s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset
Author(s) -
Sheida Rabipour,
Sricharana Rajagopal,
Elsa Yu,
Stamatoula Pasvanis,
MarieÉlyse LafailleMagnan,
John C.S. Breitner,
M. Natasha Rajah
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-191292
Subject(s) - episodic memory , psychology , recall , brain activity and meditation , neuroscience , neuroimaging , family history , cognition , medicine , cognitive psychology , electroencephalography
Episodic memory decline is one of the earliest symptoms of late-onset Alzheimer's disease (AD). Older adults with the apolipoprotein E ɛ4 (+APOE4) genetic risk factor for AD may exhibit altered patterns of memory-related brain activity years prior to initial symptom onset.