Open AccessDysregulation of CO2-Driven Heart-Rate Chemoreflex Is Related Closely to Impaired CO2 Dynamic Vasomotor Reactivity in Mild Cognitive Impairment Patients
Author(s) -
Vasilis Z. Marmarelis,
Dong-Joon Shin,
Rong Zhang
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-191238
Subject(s) - baroreflex , cerebral autoregulation , heart rate , cardiology , medicine , cerebral blood flow , blood pressure , cognitive impairment , autoregulation , neuroscience , psychology , disease
Significant reduction of dynamic vasomotor reactivity (DVR) was recently reported in patients with amnestic mild cognitive impairment (MCI) relative to age-matched controls. These results were obtained via a novel approach that utilizes data-based predictive dynamic models to quantify DVR.