Open AccessWorking Towards a Blood-Derived Gene Expression Biomarker Specific for Alzheimer’s Disease
Author(s) -
Hamel Patel,
Raquel Iniesta,
Daniel Ståhl,
Richard Dobson,
Stephen Newhouse
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-191163
Subject(s) - biomarker , medicine , amyotrophic lateral sclerosis , disease , cohort , oncology , rheumatoid arthritis , multiple sclerosis , coronary artery disease , case control study , immunology , biology , biochemistry
The typical approach to identify blood-derived gene expression signatures as a biomarker for Alzheimer's disease (AD) have relied on training classification models using AD and healthy controls only. This may inadvertently result in the identification of markers for general illness rather than being disease-specific.