Open AccessIndividual Differences in the Effects of Physical Activity on Cognitive Function in People with Mild to Moderate Dementia
Author(s) -
Iris L. Uijen,
Justine A. Aaronson,
Esther G.A. Karssemeijer,
Marcel G M Olde Rikkert,
Roy P.C. Kessels
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-190606
Subject(s) - dementia , cognition , gerontology , psychology , physical activity , medicine , clinical psychology , developmental psychology , psychiatry , physical medicine and rehabilitation , disease
The aim of this study was to investigate whether the effect of physical activity on cognitive function in persons with dementia is moderated by patient characteristics as Apolipoprotein E and dementia type. We included 101 individuals with dementia and calculated the reliable change index to determine the change in global cognition, executive function, episodic memory, working memory, and processing speed before and after a 12-week exercise training. We found a higher treatment-related benefit in episodic memory in persons with non-Alzheimer's disease compared to persons with Alzheimer's disease, and in executive function in individuals with better baseline cognitive function.