Open AccessUnitized curtain wall systems have been widely seen on high-rise buildings’ facades by bringing benefits with regard to ease of construction, lightness, etc. However, some design and application problems related to structural and infiltration performance of a facade system might arise during its life cycle, which is difficult for the building to compensate. This paper presents a comparative analysis of the structural and infiltration performance of the two identically detailed and produced unitized curtain wall system mock-ups. In order to understand long-term environmental effects on the curtain wall system, a fatigue process was applied on one system in addition to the standard test procedures, while the standard test procedure was applied on the other reference specimen. The tests on the two identical specimens were conducted in accordance with TS EN 13830 and AAMA 501.4 Standards. As a result of air infiltration and wind load resistance tests, air infiltration and frontal deflection values on the facade surface were obtained. Hence, experimental performance of the systems was compared and the effect of the fatigue procedure on the facade performance was evaluated.