Open AccessNicotinamide Mononucleotide Prevents Cisplatin-Induced Mitochondrial Defects in Cortical Neurons Derived from Human Induced Pluripotent Stem Cells
Author(s) -
Mohammad Abdur Rashid,
Alfredo Oliveros,
Yu Shin Kim,
MiHyeon Jang
Publication year - 2022
Publication title -
brain plasticity
Language(s) - English
Resource type - Journals
eISSN - 2213-6312
pISSN - 2213-6304
DOI - 10.3233/bpl-220143
Subject(s) - nicotinamide mononucleotide , cisplatin , neurotoxicity , neurogenesis , mitochondrion , microbiology and biotechnology , neuroregeneration , reactive oxygen species , neurodegeneration , dna damage , neuroprotection , cancer research , biology , chemistry , neuroscience , nad+ kinase , biochemistry , nicotinamide adenine dinucleotide , pathology , medicine , chemotherapy , toxicity , genetics , disease , enzyme , dna
Chemotherapy-induced cognitive impairment (CICI) is a neurotoxic side effect of chemotherapy that has yet to have an effective treatment.