Open AccessCardiorespiratory Fitness Associates with Cerebral Vessel Pulsatility in a Cohort Enriched with Risk for Alzheimer’s Disease
Author(s) -
Kaitlin M. Maxa,
Carson Hoffman,
Leonardo A. RiveraRivera,
Alice Motovylyak,
Patrick A. Turski,
Carol Mitchell,
Yue Ma,
Sara E. Berman,
Catherine L. Gallagher,
Barbara B. Bendlin,
Sanjay Asthana,
Mark A. Sager,
Bruce P. Hermann,
Sterling C. Johnson,
Dane B. Cook,
Oliver Wieben,
Ozioma C. Okonkwo
Publication year - 2020
Publication title -
brain plasticity
Language(s) - English
Resource type - Journals
eISSN - 2213-6312
pISSN - 2213-6304
DOI - 10.3233/bpl-190096
Subject(s) - medicine , cardiorespiratory fitness , cardiology , body mass index , risk factor , internal carotid artery , basilar artery , dementia , middle cerebral artery , disease , ischemia
There is increasing evidence that vascular disease risk factors contribute to evolution of the dementia syndrome of Alzheimer's disease (AD). One important measure of cerebrovascular health is pulsatility index (PI) which is thought to represent distal vascular resistance, and has previously been reported to be elevated in AD clinical syndrome. Physical inactivity has emerged as an independent risk factor for cardiovascular disease.