Open AccessInteraction Mechanism Between the HSV-1 Glycoprotein B and the Antimicrobial Peptide Amyloid-β
Author(s) -
Karine Bourgade,
Éric Frost,
Gilles Dupuis,
Jacek M. Witkowski,
Laurent Beaugerie,
Charles Calmettes,
Charles Ramassamy,
Mathieu Desroches,
Serafim Rodrigues,
Tamàs Fülöp
Publication year - 2022
Publication title -
journal of alzheimer's disease reports
Language(s) - English
Resource type - Journals
ISSN - 2542-4823
DOI - 10.3233/adr-220061
Subject(s) - förster resonance energy transfer , glycoprotein , biology , amyloid (mycology) , peptide , intracellular , population , microbiology and biotechnology , virology , chemistry , biophysics , biochemistry , medicine , physics , botany , environmental health , quantum mechanics , fluorescence
Unravelling the mystery of Alzheimer's disease (AD) requires urgent resolution given the worldwide increase of the aging population. There is a growing concern that the current leading AD hypothesis, the amyloid cascade hypothesis, does not stand up to validation with respect to emerging new data. Indeed, several paradoxes are being discussed in the literature, for instance, both the deposition of the amyloid-β peptide (Aβ) and the intracellular neurofibrillary tangles could occur within the brain without any cognitive pathology. Thus, these paradoxes suggest that something more fundamental is at play in the onset of the disease and other key and related pathomechanisms must be investigated.