Open AccessThe Added Value of Cerebrospinal Fluid Neurofilament Light Chain to Existing Diagnostic Methods and Biomarkers in a Mixed Memory Clinic Cohort of Consecutive Patients
Author(s) -
Helena Sophia Gleerup,
Anja Hviid Simonsen,
Peter Høgh
Publication year - 2022
Publication title -
journal of alzheimer's disease reports
Language(s) - English
Resource type - Journals
ISSN - 2542-4823
DOI - 10.3233/adr-210047
Subject(s) - cerebrospinal fluid , medicine , cohort , memory clinic , neurology , etiology , medical diagnosis , cohort study , disease , pathology , gastroenterology , cognitive impairment , psychiatry
The added value of neurofilament light chain (NfL) to the existing diagnostic methods is unknown, although a plethora of studies have shown increased levels in cerebrospinal fluid (CSF) and blood in many neurodegenerative and neurological disorders. The added value of CSF NfL was determined in a mixed memory clinic cohort of consecutive patients for 136 patients with Alzheimer’s disease (AD) (n = 69), mild cognitive impairment (n = 24), non-AD (n = 34), and also healthy controls (n = 9). This study found no increase in the diagnostic accuracy of the etiological diagnoses but knowing the CSF NfL value led to increased diagnostic certainty for the specialist in neurology.