Open AccessSuperior Frontal Gyrus TOMM40-APOE Locus DNA Methylation in Alzheimer’s Disease
Author(s) -
Natalia Ewa Bezuch,
Steven Bradburn,
Andrew C Robinson,
Neil Pendleton,
Antony Payton,
Chris Murgatroyd
Publication year - 2021
Publication title -
journal of alzheimer's disease reports
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2542-4823
DOI - 10.3233/adr-201000
Subject(s) - apolipoprotein e , dna methylation , methylation , neuropathology , cpg site , allele , biology , locus (genetics) , genotype , genetics , alzheimer's disease , promoter , gene , medicine , disease , gene expression
The APOE ɛ4 allele is the strongest known genetic risk factor for sporadic Alzheimer's disease (AD). The neighboring TOMM40 gene has also been implicated in AD due to its close proximity to APOE .