Open AccessCorrelative Microscopy to Localize and Characterize Iron Deposition in Alzheimer’s Disease
Author(s) -
Steven J. Madsen,
Phillip DiGiacomo,
Yitian Zeng,
Maged Goubran,
Yuanxin Chen,
Brian K. Rutt,
Donald E. Born,
Hannes Vogel,
Robert Sinclair,
Michael Zeineh
Publication year - 2020
Publication title -
journal of alzheimer's disease reports
Language(s) - English
Resource type - Journals
ISSN - 2542-4823
DOI - 10.3233/adr-200234
Subject(s) - scanning transmission electron microscopy , chemistry , colocalization , transmission electron microscopy , ferrous , scanning electron microscope , electron microscope , materials science , biology , nanotechnology , neuroscience , physics , organic chemistry , optics , composite material
Recent evidence suggests that the accumulation of iron, specifically ferrous Fe 2+ , may play a role in the development and progression of neurodegeneration in Alzheimer's disease (AD) through the production of oxidative stress.