Open AccessGliosis Precedes Amyloid-β Deposition and Pathological Tau Accumulation in the Neuronal Cell Cycle Re-Entry Mouse Model of Alzheimer’s Disease
Author(s) -
Kevin H.J. Park,
Thomas J. Barrett
Publication year - 2020
Publication title -
journal of alzheimer's disease reports
Language(s) - English
Resource type - Journals
ISSN - 2542-4823
DOI - 10.3233/adr-200170
Subject(s) - microglia , neurodegeneration , neuroinflammation , genetically modified mouse , gliosis , biology , pathology , astrocyte , transgene , alzheimer's disease , senile plaques , astrogliosis , neuroscience , immunology , medicine , central nervous system , disease , inflammation , gene , biochemistry
The presence of cell cycle markers in postmortem Alzheimer's disease (AD) brains suggest a potential role of cell cycle activation in AD. It was shown that cell cycle activation in postmitotic neurons in mice produces Aβ and tau pathologies from endogenous mouse proteins in the absence of AβPP or tau mutations.