Open AccessMental Disorders in Young Adults from Families with the Presenilin-1 Gene Mutation E280A in the Preclinical Stage of Alzheimer’s Disease
Author(s) -
Arvey Camilo Villalba,
Jenny García,
Cláudia Ramos,
Amanda Cuastumal,
David Aguillón,
Daniel Camilo Aguirre–Acevedo,
Lucía Madrigal,
Francisco Lopera
Publication year - 2019
Publication title -
journal of alzheimer's disease reports
Language(s) - English
Resource type - Journals
ISSN - 2542-4823
DOI - 10.3233/adr-190139
Subject(s) - psen1 , presenilin , disease , family history , mutation , medicine , dementia , alzheimer's disease , psychiatry , genetics , psychology , oncology , gene , biology
There are forms of Alzheimer's disease (AD) that have an autosomal dominant inheritance pattern; one of them is caused by the E280A mutation in the gene that codes for Presenilin-1 ( PSEN1 ). Studying families of people with this mutation allows the evaluation of characteristics of the subjects before cognitive decline begins.