Open AccessPathological examination of breast cancer samples before and after neoadjuvant therapy: recommendations from the Italian Group for the Study of Breast Pathology - Italian Society of Pathology (GIPaM-SIAPeC)
Author(s) -
Nicola Fusco,
Antonio Rizzo,
Leopoldo Costarelli,
Alfredo Santinelli,
Bruna Cerbelli,
Cristian Scatena,
Ettore Macrì,
Francesca Pietribiasi,
Giulia d’Amati,
Anna Sapino,
Isabella Castellano
Publication year - 2022
Publication title -
pathologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.243
H-Index - 18
eISSN - 1591-951X
pISSN - 0031-2983
DOI - 10.32074/1591-951x-747
Subject(s) - medicine , breast cancer , pathological , neoadjuvant therapy , adjuvant therapy , nat , surgical pathology , cancer , pathology , oncology , anatomical pathology , computer network , computer science
Neoadjuvant therapy (NAT) in breast cancer is administered to downstage the tumor, de-escalate surgery, and provide prognostic information that can be used to tailor subsequent adjuvant therapy. In this respect, the pathological evaluation of both pre-NAT biopsies and post-NAT surgical specimens is crucial to precisely assess the treatment response. With the increasing possibilities of NAT protocols and the rising number of eligible patients, it has become extremely important to standardize the pathological response assessment. Here, we provide an update on the recommendations of the Italian Group for the Study of Breast Pathology - the Italian Society of Pathology (GIPaM-SIAPeC) for the analysis of breast cancer samples before and after NAT.