Open AccessCoexistence of two missense mutations in the KRAS gene in adenocarcinoma of the lung: a possible indicator of poor prognosis
Author(s) -
Manuela Spinelli,
Persephone Du Parcq,
Nandita Gupta,
Jamshid S. Khorashad,
Patrizia Viola
Publication year - 2022
Publication title -
pathologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.243
H-Index - 18
eISSN - 1591-951X
pISSN - 0031-2983
DOI - 10.32074/1591-951x-334
Subject(s) - kras , missense mutation , adenocarcinoma , lung cancer , medicine , exon , pathology , lung , oncology , cancer research , mutation , cancer , biology , gene , colorectal cancer , genetics
KRAS mutations are present in up to 30% of patients with lung adenocarcinoma. The two most common KRAS mutations in non-small cell lung cancer (NSCLC) are G12C (~40%) and G12V (~22%). We describe the case of a 63-year-old Asian male patient with a very aggressive lung adenocarcinoma harbouring two coexisting missense mutations in the same exon.