Open AccessPathology of autoimmune hepatitis
Author(s) -
Claudia Covelli,
Diana Sacchi,
Samantha Sarcognato,
Nora Cazzagon,
Federica Grillo,
Francesca Baciorri,
Daniela Fanni,
Matilde Cacciatore,
Valeria Maffeis,
Maria Guido
Publication year - 2021
Publication title -
pathologica
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.243
H-Index - 18
eISSN - 1591-951X
pISSN - 0031-2983
DOI - 10.32074/1591-951x-241
Subject(s) - autoimmune hepatitis , medicine , hypergammaglobulinemia , immunosuppression , liver biopsy , genetic predisposition , pathological , hepatitis , autoantibody , disease , immunology , liver disease , pathology , biopsy , antibody
Autoimmune hepatitis (AIH) is a relatively rare non-resolving chronic liver disease, which mainly affects women. It is characterized by hypergammaglobulinemia, circulating autoantibodies, interface hepatitis on liver histology and a favourable response to immunosuppression. The putative mechanism for the development of autoimmune hepatitis is thought to be the interaction between genetic predisposition, environmental triggers and failure of the native immune system.