Open AccessSynthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity
Author(s) -
Omeed M. Hassan,
Susan W. Sarsam
Publication year - 2019
Publication title -
al-maǧallaẗ al-’irāqiyyaẗ li-l-’ulūm al-ṣaydalāniyyaẗ/iraqi journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 1
eISSN - 2521-3512
pISSN - 1683-3597
DOI - 10.31351/vol28iss1pp107-113
Subject(s) - etodolac , chemistry , anti inflammatory , edema , pharmacology , hydrazone , stereochemistry , biochemistry , medicine , surgery
A series of Etodolac hydrazone derivatives were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy and 1HNMR analysis. The synthesized target compounds (P1-P3) were found to be active in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Etodolac).
Keywords: Etodolac hydrazone derivatives, anti-inflammatory, paw edemamethod.