Open AccessEndometrial carcinoma following chronic anovulation in a premenopausal woman with systemic lupus erythematosus
Author(s) -
Sekiya S.,
Iwasaki H.,
Takeda B.,
Takamizawa H.
Publication year - 1988
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348809029869
Subject(s) - medicine , anovulation , atypical hyperplasia , dysfunctional uterine bleeding , carcinoma , endometrial hyperplasia , estrogen , hyperplasia , endometrial polyp , adenocarcinoma , gastroenterology , gynecology , endometrium , oncology , cancer , insulin resistance , polycystic ovary , insulin
Endometrial carcinoma was diagnosed in a premenopausal woman suffering with systemic lupus erythematosus. She had received both predonisolone and an im‐munosuppressive agent for more than 10 years. Anovulatory cycles persisted during drug administration, along with dysfunctional uterine bleeding. The serum estrogen: progesterone ratio was high. Repeated endometrial biopsies revealed a progression of change from benign proliferation to cystic hyperplasia, adenomatous hyperplasia, atypical hyperplasia and invasive adenocarcinoma. These clinical data suggest that a result of long‐term unopposed endogenous estrogen can have been the cause of the endometrial carcinoma.