Open AccessSIDE‐EFFECTS OF PROSTAGLANDIN SYNTHETASE INHIBITORS
Author(s) -
Andersson KarlErik
Publication year - 1979
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347909157801
Subject(s) - medicine , dyscrasia , bronchospasm , phenylbutazone , oxyphenbutazone , adverse effect , side effect (computer science) , gastrointestinal tract , pharmacology , prostaglandin , asthma , plasma cell , computer science , multiple myeloma , programming language
. A short review is given of some of the adverse reactions to prostaglandin synthetase inhibitors. Broadly, these side‐effects can be divided into those common to the whole group, and those more or less characteristic of the individual drugs. Among the former, symptoms from the gastrointestinal tract and from the central nervous system are the most conspicuous. Skin reactions, bronchospasm, and serious blood dyscrasias have been reported for several of these drugs and the list of more rare side‐effects is long. It is concluded that drugs like phenylbutazone and oxyphenbutazone should not be used for treatment of dysmenorrhea because of the risks of serious adverse reactions. However, even if among the newly introduced compounds none can be said to be free from risks, some seem to have an acceptable ratio between therapeutic efficacy and side‐effects.