Open AccessHeterologous Growth of Human Ovarian Cancer: A New in Vivo Testing System
Author(s) -
Davy Margaret,
Mossige Jeanne,
Johannessen Jan V.
Publication year - 1977
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347709158340
Subject(s) - thiotepa , medicine , ovarian cancer , in vivo , cancer , cancer research , pathology , oncology , chemotherapy , biology , genetics , cyclophosphamide
. Successful heterotransplantation of ovarian cancer in the mouse mutant, nude is described, with serial transmission, in one case to date. Light and electron microscopic examination of this tumour, a poorly differentiated adenocarcinoma, has not revealed any alteration in its morphology after six passages. Tumour‐bearing mice have been treated with ThioTEPA or 5‐Fluoro‐Uracil, in an attempt to see if they show a similar effect to that seen in the patient. ThioTEPA resulted in a marked regression, whilst there was no effect from 5‐Fluoro‐Uracil, on tumour growth—confirming the ThioTEPA effect seen in the patient.