Open AccessSimultaneous Spectrophotometric Estimation of Telmisartan and Amlodipine Besylate in Tablet Dosage Form
Author(s) -
Nandini Gupta,
Ashok Peepliwal,
Devendra Singh Rathore,
Pooja Gupta
Publication year - 2015
Publication title -
indian journal of pharmaceutical and biological research
Language(s) - English
Resource type - Journals
ISSN - 2320-9267
DOI - 10.30750/ijpbr.3.3.8
Subject(s) - amlodipine , telmisartan , chromatography , dosage form , robustness (evolution) , mathematics , chemistry , medicine , biochemistry , blood pressure , gene
A simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Telmisartan (TEL) and Amlodipine Besylate (AML) in combined tablet dosage forms. The method involves determination using the simultaneous equation method, the sampling wavelengths selected are ‘TLM’ = 297nm.and ‘AML’ =238nm., over the concentration ranges of 8-48μg/ml for ‘TEL’ and 1-6 μg/ml for ‘AML’ respectively. The method was validated for linearity, accuracy, precision, robustness and application for assay as per ICH guidelines. The proposed method is simple, economical, accurate and precise, and could be successfully employed in routine quality control for the simultaneous analysis of Telmisartan (TEL) and Amlodipine Besylate (AML).