Open AccessPengaruh Pemberian Asam Alfa Lipoat terhadap Kadar Kolesterol Total pada Tikus Diabetes Melitus Tipe 2
Author(s) -
Uli Kartika Lestari Sinaga,
Ismawati Ismawati,
Enikarmila Asni
Publication year - 2018
Publication title -
jurnal ilmu kedokteran /jurnal ilmu kedokteran
Language(s) - English
Resource type - Journals
eISSN - 2715-4467
pISSN - 1978-662X
DOI - 10.26891/jik.v11i2.2017.18-23
Subject(s) - type 2 diabetes , diabetes mellitus , medicine , nicotinamide , endocrinology , streptozotocin , cholesterol , body weight , total cholesterol , chemistry , biochemistry , enzyme
Hypercholesterolemia is complication in type 2 diabetes. Alpha lipoic acid (ALA) reduced total cholesterol by modulatingcholesterol synthesis pathway and reduced cholesterol biosynthesis genes expression. The goal of this research wasto investigate the prohibition of hypercholesterolemia in type 2 diabetes rat by ALA. Fifteen adult male wistar rats (2-3 months, 200-250 g body weight) were segregated into three groups (standard, type 2 diabetes and type 2 diabetes +ALA). Type 2 diabetes induced by streptozotocin 65 mg/kg and nicotinamide 110 mg/kg. ALA was given for 3 weeksafter type 2 diabetes induced.After 31 days total cholesterol of groups labelled is measured. The result showed therewas significant difference between ALA and type 2 diabetes groups (p= 0.012), and there was no significant differencebetween ALA and standard groups (p= 0.591). As the conclusion, this study proves that ALA has effects on totalcholesterol in type 2 diabetes rats.