Open AccessA Systematic Review and Meta-Analysis on Gualou Niubang Decoction for Acute Mastitis
Author(s) -
Tian-tian Gao,
Shuo Zhang,
Zhenlin Chen,
Miao Wang,
Hongyan Wang,
Wei Ma,
Lu Wang
Publication year - 2022
Publication title -
journal of clinical and nursing research
Language(s) - English
Resource type - Journals
eISSN - 2208-3693
pISSN - 2208-3685
DOI - 10.26689/jcnr.v6i1.2899
Subject(s) - medicine , decoction , cochrane library , meta analysis , randomized controlled trial , white blood cell
Objective: To systematically evaluate the clinical efficacy of Gualou Niubang decoction in the treatment of acute mastitis. Methods: Randomized controlled trials of Gualou Niubang decoction in the treatment of acute mastitis included in PubMed, Springer, Embase, Cochrane Library, CNKI, Wanfang, Weipu, and China Biomedical Literature Database from January 2016 to present. The Cochrane risk bias assessment tool was used to evaluate the risk of bias. Used Revman 5.3 software for Meta analysis. Results: There are 8 articles that meet the inclusion criteria, comprising 919 subjects, the test group were 462, cases and control group were 457 cases. The results of statistical analysis showed that the clinical efficacy of the experimental group was significantly higher than which of the control group, [RR = 1.19, 95% CI (1.07, 1.33), P = 0.002], the difference was statistically significant. Among the secondary outcome indicators, compared to the control group, Gualou Niubang decoction can effectively relieve the main symptoms of acute mastitis [MD = -1.96, 95% CI (-2.27, -1.65), P<0.0001]. Gualou Niubang decoction combined with antibiotics can shorten the length of hospital stay [MD=-5.23,95% CI (-6.02, -4.44), P<0.00001] and reduce white blood cell count [MD = -2.40, 95%CI (-4.71, -0.08), P = 0.04] are better than antibiotics. Conclusion: The use of Gualou Niubang decoction to treat acute mastitis can not only improve clinical efficacy, but also effectively relieve clinical symptoms, shorten hospital stay and reduce white blood cell count.