Open AccessCOVID-19 and features of cardiovascular involvement
Author(s) -
Е. В. Цыганова,
Nataliia V. Glukhoedova,
Aleksandra S. Zhilenkova,
Tatiana I. Fedoseeva,
Е. Н. Ющук,
Н.С. Сметнева
Publication year - 2021
Publication title -
terapevtičeskij arhiv
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.181
H-Index - 14
eISSN - 2309-5342
pISSN - 0040-3660
DOI - 10.26442/00403660.2021.09.201036
Subject(s) - medicine , pathogenesis , coagulopathy , disease , inflammation , covid-19 , endothelial dysfunction , presentation (obstetrics) , immunology , pathology , bioinformatics , intensive care medicine , infectious disease (medical specialty) , cardiology , surgery , biology
The article provides an overview of current information on the pathogenesis of COVID-19 and organ-specific lesions developing in this disease. The data on inflammation and its biochemical markers, on the features of coagulopathy, endothelial damage and microthrombosis are presented in detail. Particular attention is paid to the role of receptors for angiotensin converting enzyme type 2 and transmembrane serine protease type 2 in the development of organ-specific lesions in COVID-19. The pathogenesis of damage to the cardiovascular system is considered in detail with the presentation of data from foreign literature on changes in the myocardium and the author's results of transthoracic echocardiographic examination in patients who have undergone COVID-19.