Open Access?-Fluoro-Benzylphosphonates as Reagents for the Preparation of 1-Fluoro-1-Aryl Alkenes and ?-Fluorostilbenes
Author(s) -
Thomas Allmendinger,
Roger A. Fujimoto,
F. Gasparini,
W. M. Schilling,
Y. Satoh
Publication year - 2004
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942904777678217
Subject(s) - aryl , reagent , chemistry , combinatorial chemistry , organic chemistry , alkyl
The preparation of several fluoro-benzylphosphonates Ar-CHF-PO(OEt)2 and their Wadsworth-Emmons type olefination with aldehydes and ketones are described affording fluorostyrenes and fluorostilbenes. Some of these compounds are incorporated into target molecules tested as drug candidates.