Open AccessSelective Release of Technetium Complexes from a Solid Phase due to C–N Bond Cleavage upon Metal Coordination
Author(s) -
Stefan Mundwiler,
Lukas Candreia,
Roger Alberto
Publication year - 2003
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942903777679514
Subject(s) - bond cleavage , cleavage (geology) , chemistry , metal , technetium , phase (matter) , molecule , combinatorial chemistry , radiochemistry , materials science , nuclear chemistry , organic chemistry , catalysis , fracture (geology) , composite material
A new method for 99mTc-labeling using solid-phase technology is described. It allows the separation of unlabeled from labeled bioactive molecules by simple filtration. The procedure is based on a site-specific C–N bond cleavage reaction initiated by the formation of [TcI(CO)3L]-complexes.