Open AccessTowards the Directed Evolution of Hybrid Catalysts
Author(s) -
Manfred T. Reetz,
Martin Rentzsch,
Andreas Pletsch,
Matthias Maywald
Publication year - 2002
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942902777679920
Subject(s) - moiety , catalysis , covalent bond , mutagenesis , chemistry , combinatorial chemistry , directed evolution , stereochemistry , organic chemistry , mutation , biochemistry , gene , mutant
The first step in applying the recently proposed concept concerning the application of directed evolution to the creation of selective hybrid catalysts is described, specifically the covalent attachment of Mn-salen moieties and of Cu-, Pd-, and Rh-complexes of dipyridine derivatives as well as the implantation of a diphosphine moiety in a protein, future steps being cycles of mutagenesis/screening