Open AccessCorrelation between mandibular bone density, CD4 T-cells, and duration of HAART in HIV-infected children
Author(s) -
Intan Maulani,
Risti Saptarini Primarti,
Irna Sufiawati,
Ratna Indriyanti,
Niekla Survia Andiesta
Publication year - 2021
Publication title -
padjajaran journal of dentistry/padjadjaran journal of dentistry
Language(s) - English
Resource type - Journals
eISSN - 2549-6212
pISSN - 1979-0201
DOI - 10.24198/pjd.vol33no1.15894
Subject(s) - medicine , osteopenia , osteoporosis , bone density , bone mineral , dentistry , densitometry , correlation , geometry , mathematics
Perinatal HIV infection has decreased adverse bone health effects and mineral accrual. HIV-infected patients have a multifactorial origin, including HIV bone cell infections, inflammatory cytokine effects on osteoblast and osteoclast activity, and HAART. The research objective was to examine the correlation between the mandibular bone density and CD4 T-cells with HAART duration in HIV-infected children. Methods: The mandibular bone density in the HIV-infected pediatric population was evaluated using a panoramic radiograph. The research design was a cross-sectional and univariate regression analysis for the sampling method. Mandibular density analysis using Spearman and Pearson correlation and HAART duration using Kendall correlation. Thirty-five HIV-infected children and seventeen non-HIV-infected children were recruited. Results: This study showed the correlation between HIV and non-HIV infected children (p<0.05). The correlation between CD4 T-cells and mandibular bone density was significant (p<0.05). Long term HAART and mandibular bone density have a significant correlation (p<0.001). This research showed correlations between mandibular bone density CD4 T-cells and duration of HAART in HIV-infected children. Conclusion: HIV-infected children require a regular mandibular cortical bone examination to detect the onset of osteopenia and osteoporosis to obtain appropriate therapy.