
In Vitro study for hesperidin nanoparticles effect on phagocytic activity against Staphylococcus aureus
Author(s) -
Saja H Ali,
Ghassan M. Sulaiman,
Mohammed M. F. Al-Halbosiy
Publication year - 2018
Publication title -
maǧallaẗ markaz buḥūṯ al-taqniyyaẗ al-aḥyāʾiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2708-1370
pISSN - 1815-1140
DOI - 10.24126/jobrc.2018.12.2.536
Subject(s) - hesperidin , chemistry , nanoparticle , fourier transform infrared spectroscopy , flavonoid , nuclear chemistry , antioxidant , nanotechnology , materials science , biochemistry , chemical engineering , medicine , alternative medicine , pathology , engineering
Hesperidin is one of the flavonoids from citrus peels and it recognized to possess various biological activities such as, anti-inflammatory, anti-carcinogenic, antioxidant and antimicrobial potentials. The present investigation studies the immunological adjuvant influence of hesperidin nanoparticles. Hesperidin nanoparticles were prepared by nano-precipitation technique by using Poly (D, L-lactic-co-glycolic acid) (PLGA) polymer and Poloxamer 407 was used as a stabilizer. This method was used because of their advantage of low setup cost and simplicity. Hesperidin nanoparticles were characterized by fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and particle size analysis (PSA) analytical methods. The effect of hesperidin nanoparticles was higher than the effect of pure hesperidin, and there was an obvious increase in phagocytosis index (PI 82%) of hesperidin nanoparticles when compared with pure hesperidin (PI 56%) and in comparison with the control samples (PI 22%). In conclusion we need further studies about if nano-hesperidin has therapeutic effects.