Open AccessSafety considerations during prescription of non-steroidal anti-inflammatory drugs (NSAIDs), through a review of systematic reviews
Author(s) -
Antonio Olry de Labry Lima,
Elena Salamanca-Fernández,
EJ Alegre-Del Rey,
Antonio Matas Hoces,
Manel Vera,
Clara Bermúdez Tamayo
Publication year - 2021
Publication title -
anales del sistema sanitario de navarra
Language(s) - English
Resource type - Journals
eISSN - 2340-3527
pISSN - 1137-6627
DOI - 10.23938/assn.0965
Subject(s) - medicine , medical prescription , exacerbation , intensive care medicine , cirrhosis , kidney disease , narrative review , population , heart failure , pharmacology , environmental health
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide. This makes it necessary to carry out a comprehensive synthesis of the available evidence on the safe and adequate prescription of NSAIDs in patients with cardiovascular disease, chronic kidney disease, hypertension, heart failure or liver cirrhosis and in general population. For this, a review of systematic reviews was carried out. Data extraction and analysis were performed independently by two reviewers and a narrative synthesis of the results was carried out. The use of NSAIDs is associated with a significantly higher probability of hepatotoxicity and kidney damage, as well as increased risk of exacerbation of heart failure. Taking into account the increased cardiovascular, liver and kidney risk, the prescription of NSAIDs should be carried out with caution, considering the treatment duration and the patient's situation. For this reason, patients should be informed about their possible health consequences as well as ensuring adequate monitoring of them.