Behavioral and electroencephalographic effects of delta sleep inducing peptide and its analogue on metaphit-induced audiogenic seizures in rats | Zendy

Olivera Stanojlović | Zendy; Dragana Zivanovic | Zendy; Slobodan Mirković | Zendy; Danijela Vučević | Zendy

Open Access

Behavioral and electroencephalographic effects of delta sleep inducing peptide and its analogue on metaphit-induced audiogenic seizures in rats

Author(s) -

Olivera Stanojlović,

Dragana Zivanovic,

Slobodan Mirković,

Danijela Vučević

Publication year - 2004

Publication title -

srpski arhiv za celokupno lekarstvo

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.135

H-Index - 17

eISSN - 2406-0895

pISSN - 0370-8179

DOI - 10.2298/sarh0412421s

Subject(s) - medicine , electroencephalography , sleep (system call) , neuroscience , psychiatry , psychology , computer science , operating system

Delta sleep inducing peptide (DSIP) is well known natural somnogenic peptide that has many other physiological functions. DSIP analogues representing hepta- and octapeptides (also known as long) as well as tetrapeptide (termed short, used in our experiments) were synthesized with a view to evaluate the peptide specificity in sleep. The effects of DSIP and its analogue DSIP1-4 on metaphit 1-[1(3-isothiocyanatophenylciclohexyl)-piperidine] induced audiogenic seizures were evaluated in rats.

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