Open AccessBehavioral and electroencephalographic effects of delta sleep inducing peptide and its analogue on metaphit-induced audiogenic seizures in rats
Author(s) -
Olivera Stanojlović,
P Dragana Zivanovic,
Slobodan Mirković,
Danijela Vučević
Publication year - 2004
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh0412421s
Subject(s) - medicine , electroencephalography , sleep (system call) , neuroscience , psychiatry , psychology , computer science , operating system
Delta sleep inducing peptide (DSIP) is well known natural somnogenic peptide that has many other physiological functions. DSIP analogues representing hepta- and octapeptides (also known as long) as well as tetrapeptide (termed short, used in our experiments) were synthesized with a view to evaluate the peptide specificity in sleep. The effects of DSIP and its analogue DSIP1-4 on metaphit 1-[1(3-isothiocyanatophenylciclohexyl)-piperidine] induced audiogenic seizures were evaluated in rats.