Open AccessBiomarkers for suicidal behavior: miRNAs and their potential for diagnostics through liquid biopsy – a systematic review
Author(s) -
Katarina Kouter,
Alja Videtič Paska
Publication year - 2020
Publication title -
epigenomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.265
H-Index - 60
eISSN - 1750-1911
pISSN - 1750-192X
DOI - 10.2217/epi-2020-0196
Subject(s) - microrna , microvesicles , liquid biopsy , biology , extracellular vesicles , bioinformatics , extracellular vesicle , computational biology , neuroscience , gene , genetics , microbiology and biotechnology , cancer
Background: Given that approximately 70% of miRNAs in the body are neuronal, we critically assessed current studies on miRNAs and suicidal behavior. Materials & Methods: To further define the role of miRNAs in suicide, we searched for studies on extracellular vesicles (exosomes) because miRNAs are particularly enriched in exosomes. miRNAs also have important physiological roles, and they can cross the blood–brain barrier and participate in cell-to-cell communication with both nearby and distant cells. Results & Conclusion: This critical assessment suggests that several miRNAs can be closely related to neurophysiology, suicidal behavior, and psychiatric disorders. However, clear overlap is poor due to either different methodologies applied or to molecular differences between suicidal behaviors and studied psychiatric disorders.