Open AccessPROPHYLACTIC ANTIBIOTICS ALONE VERSUS COMBINED PROPHYLAXIS AND POSTOPERATIVE ANTIBIOTICS FOR PREVENTING SURGICAL-SITE INFECTIONS ASSOCIATED WITH EAR AND NOSE RECONSTRUCTIVE SURGERY
Author(s) -
Trimartani Koento,
Rangga Rayendra Saleh
Publication year - 2019
Publication title -
international journal of applied pharmaceutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 0975-7058
DOI - 10.22159/ijap.2019.v11s6.33534
Subject(s) - medicine , antibiotics , nose , reconstructive surgery , surgery , throat , antibiotic prophylaxis , ear nose and throat , significant difference , microbiology and biotechnology , biology
Objective: The aim of this study was to acquire supporting data for the rational use of antibiotics in plastic reconstructive surgery in the Ear-Nose-Throat/Head and Neck Surgery Department at Cipto Mangunkusumo Hospital–Faculty of Medicine Indonesia University.
Methods: This pilot study, with a negative trial design, included 12 subjects who were randomly divided into two groups: preoperative prophylactic antibiotic-only group and a combination of prophylactic and postoperative antibiotic group (controls).
Results: The results showed that only 1 of the 12 subjects (in the prophylactic antibiotic-only group) developed an SSI. None of the controls (combined-use group) had an SSI. The difference between the two groups was not significant.
Conclusion: The use of postoperative antibiotic appears not to be necessary in plastic reconstructive surgery patients to prevent SSIs. Further study, however, is required to support the findings of this study.