Open AccessAnimal Models for Microbicide Studies
Author(s) -
Ronald S. Veazey,
Robin J. Shattock,
Per Johan Klasse,
John P. Moore
Publication year - 2012
Publication title -
current hiv research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.561
H-Index - 52
eISSN - 1873-4251
pISSN - 1570-162X
DOI - 10.2174/157016212799304715
Subject(s) - microbicide , microbicides for sexually transmitted diseases , human immunodeficiency virus (hiv) , vaginal microbicide , risk analysis (engineering) , medicine , pharmacology , intensive care medicine , engineering ethics , virology , engineering , health services , environmental health , population
There have been encouraging recent successes in the development of safe and effective topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-retroviral drugs. However, much work remains to be accomplished before a microbicide becomes a standard element of prevention science strategies. Animal models should continue to play an important role in pre-clinical testing, with emphasis on safety, pharmacokinetic and efficacy testing.