Open AccessThe Roles of Alternative Splicing in Tumor-immune Cell Interactions
Author(s) -
Yue Wang,
Honglei Zhang,
Baowei Jiao,
Jianyun Nie,
Xi-Yin Li,
Wenhuan Wang,
Hairui Wang
Publication year - 2020
Publication title -
current cancer drug targets
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 91
eISSN - 1873-5576
pISSN - 1568-0096
DOI - 10.2174/1568009620666200619123725
Subject(s) - immune system , alternative splicing , rna splicing , neuroscience , computational biology , biology , microbiology and biotechnology , immunology , genetics , gene , rna , messenger rna
Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms involved in AS-mediated innate and adaptive immune responses and the anti-tumoral and protumoral roles in different types of cancer. For example, ULBP1_RI, MLL5Δ21spe, NKp44-1Δ5, MHC-IΔ7, CD200SΔ1, 2, PVR α/β/γ/δ and IL-33 variants 1/2/3 act as regulators in solid tumors and IPAK4-L and, FOXP1ΔN100 exhibit functions in hematological cancers.