Open AccessEffect of a Topical Formulation on Infective Viral Load in Lambs Naturally Infected with Orf Virus
Author(s) -
Delia Lacasta,
Ramsés Reina,
Héctor Ruíz,
Luís Miguel Ferrer,
Alfredo A. Benito,
María Teresa Tejedor,
Irache Echeverría,
Héctor Ruíz,
Silvia Martinez Cardenas,
Peter Windsor
Publication year - 2021
Publication title -
veterinary medicine
Language(s) - English
Resource type - Journals
ISSN - 2230-2034
DOI - 10.2147/vmrr.s306355
Subject(s) - antiseptic , medicine , virus , antibiotics , outbreak , hygiene , virology , veterinary medicine , microbiology and biotechnology , biology , pathology
Orf is a highly contagious eruptive viral disease of the skin and mucosa of sheep and goats. Although vaccination with live or attenuated orf virus is the preferred option for disease control, the vaccine is unavailable in many countries. Treatment of orf lesions involves standard hygiene and in numerous cases, management of presumptive secondary infections with antibiotics, increasing risks of antimicrobial resistance (AMR). The wound dressing formulation Tri-Solfen ® containing two local anaesthetics (lignocaine and bupivacaine), adrenaline and an antiseptic (cetrimide) in a gel formulation was developed for pain relief in sheep undergoing surgical husbandry procedures in Australia. Recently, TS therapy was found to reduce suffering and enhance recovery in cattle and buffalo with oral and skin lesions due to foot-and-mouth disease (FMD) virus infection. It was noted that TS has a low pH and is potentially viricidal, potentially aiding disease control.